2-Bromothiazole
Base Information
- Chemical Name: 2-Bromothiazole
- CAS No.: 3034-53-5
Factory Export Top Purity 2-Bromothiazole 3034-53-5 In Stock
- Molecular Formula: C3H2BrNS
- Molecular Weight: 164.026
- Appearance/Colour: colourless liquid
- Vapor Pressure: 1.9mmHg at 25°C
- Melting Point: 171 °C
- Refractive Index: n20/D 1.593(lit.)
- Boiling Point: 170.999 °C at 760 mmHg
- PKA: 0.84±0.10(Predicted)
- Flash Point: 63.333 °C
- PSA： 41.13000
- Density: 1.857 g/cm3
- LogP: 1.90560
2-Bromothiazole(Cas 3034-53-5) Usage
|
Referrence |
Ayer, W. A.; Craw, P. A.; Ma, Y. T.; Miao, S. C., SYNTHESIS OF CAMALEXIN AND RELATED PHYTOALEXINS. Tetrahedron 1992, 48, 2919-2924. Kurkjy, R. P.; Brown, E. V., THE PREPARATION OF THIAZOLE GRIGNARD REAGENTS AND THIAZOLYLLITHIUM COMPOUNDS. J. Am. Chem. Soc. 1952, 74, 6260-6262. Beyerman, H. C.; Berben, P. H.; Bontekoe, J. S., THE SYNTHESIS OF THIAZOLE-2-CARBOXYLIC AND OF THIAZOLE-5-CARBOXYLIC ACID VIA A HALOGEN-METAL EXCHANGE REACTION. Recl. Trav. Chim. Pays-Bas-J. Roy. Neth. Chem. Soc. 1954, 73, 325-332. Misra, R. N.; Xiao, H. Y.; Williams, D. K.; Kim, K. S.; Lu, S. F.; Keller, K. A.; Mulheron, J. G.; Batorsky, R.; Tokarski, J. S.; Sack, J. S.; Kimball, D.; Lee, F. Y.; Webster, K. R., Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977. Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V., Synthesis and anti-inflammatory activity of ethynylthiazoles. Khim. Geterotsiklicheskikh Soedin. 2006, 769-774. |
InChI:InChI=1/C3H2BrNS/c4-3-5-1-2-6-3/h1-2H
3034-53-5 Relevant articles
Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer
Bandar, Jeffrey S.,Klaus, Danielle R.,Puleo, Thomas R.
supporting information, p. 12480 - 12486 (2021/08/24)
We report a general protocol for the dir...
Synthesis of Brominated Thiazoles via Sequential Bromination-Debromination Methods
Uzelac, Eric J.,Rasmussen, Seth C.
, p. 5947 - 5951 (2017/06/07)
The synthesis of the full family of brom...
Synthetic method for 2-acetyl thiazole
-
Paragraph 0048; 0049, (2016/10/08)
The invention relates to a synthetic met...
ALKYNE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS
-
Page/Page column 142, (2016/05/02)
Provided are compounds of formula (Ia) a...
3034-53-5 Process route
-
-
96-50-4
2-thiazolylamine
-
-
3034-53-5,215777-74-5
2-bromo-1,3-thiazole
| Conditions | Yield |
|---|---|
|
With
copper(II) sulphate hydrate; phosphoric acid; nitric acid; sodium bromide; sodium nitrite;
In
water;
at 0 - 7 ℃;
for 6h;
|
86%
|
|
2-thiazolylamine;
With
sulfuric acid; nitric acid; sodium nitrite;
In
water;
at 2 - 10 ℃;
for 1h;
With
copper(II) sulfate; sodium bromide;
In
water;
at 6 ℃;
for 8.5h;
Concentration;
|
85.8%
|
|
With
hydrogen bromide; sodium nitrite;
|
|
|
Multistep reaction;
(i) NaNO2, HNO3, H3PO4, (ii) (bromination);
|
|
|
2-thiazolylamine;
With
phosphoric acid; nitric acid;
for 0.166667h;
With
sodium nitrite;
In
water;
at 0 ℃;
for 1h;
With
copper(II) sulfate; sodium bromide;
In
water;
at 0 - 20 ℃;
for 22h;
|
2.5 g
|
|
2-thiazolylamine;
With
phosphoric acid; nitric acid; sodium nitrite;
In
water;
at 0 - 5 ℃;
for 2h;
Sonication;
Inert atmosphere;
With
copper(ll) sulfate pentahydrate; sodium bromide;
In
water;
at 0 ℃;
Sonication;
Inert atmosphere;
|
-
-
288-47-1
1,3-thiazole
-
-
3141-27-3
2,5-dibromothiophen
-
-
3034-53-5,215777-74-5
2-bromo-1,3-thiazole
| Conditions | Yield |
|---|---|
|
With
potassium tert-butylate;
In
tetrahydrofuran;
Inert atmosphere;
Glovebox;
Sealed tube;
Schlenk technique;
|
14%
|
3034-53-5 Upstream products
-
288-47-1
1,3-thiazole
-
96-50-4
2-thiazolylamine
-
3141-27-3
2,5-dibromothiophen
3034-53-5 Downstream products
-
122320-81-4
2-(methyl-thiazol-2-yl-amino)-ethanol
-
101117-32-2
N -benzyl-N ',N '-dimethyl-N -thiazol-2-yl-ethylenediamine
-
66507-95-7
4-acetylamino-N -methyl-N -thiazol-2-yl-benzenesulfonamide
-
553-13-9
Zolamine