(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid

Base Information

  • Chemical Name: (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
  • CAS No.: 20445-31-2

High Quality Chinese Factory supply 20445-31-2 (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid

  • Molecular Formula: C10H9F3O3
  • Molecular Weight: 234.175
  • Vapor Pressure: 0.164mmHg at 25°C 
  • Melting Point: 46-49 °C(lit.) 
  • Refractive Index: n20/D 1.473(lit.)  
  • Boiling Point: 287.226 °C at 760 mmHg 
  • PKA: 1.47±0.10(Predicted) 
  • Flash Point: 134.154 °C 
  • PSA： 46.53000 
  • Density: 1.35 g/cm3 
  • LogP: 2.17520 

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid(Cas 20445-31-2) Usage

General Description

Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.

InChI:InChI=1/C10H8ClF3O2/c1-16-9(8(11)15,10(12,13)14)7-5-3-2-4-6-7/h2-6H,1H3/t9-/m0/s1

20445-31-2 Relevant articles

Organocatalytic Enantioselective Vinylogous Aldol Reaction of Allyl Aryl Ketones to Activated Acyclic Ketones

Jing, Zhenzhong,Bai, Xiangbin,Chen, Wenchao,Zhang, Gao,Zhu, Bo,Jiang, Zhiyong

supporting information, p. 260 - 263 (2016/02/03)

The first catalytic asymmetric vinylogou...

Asymmetric 1,2-Perfluoroalkyl Migration: Easy Access to Enantioenriched α-Hydroxy-α-perfluoroalkyl Esters

Wang, Pan,Feng, Liang-Wen,Wang, Lijia,Li, Jun-Fang,Liao, Saihu,Tang, Yong

supporting information, p. 4626 - 4629 (2015/04/27)

This study has led to the development of...

Thioacids and thioacid salts for determining the enantiomeric excess of chiral compounds containing an electrophilic carbon center

-

Page/Page column 19-20, (2010/07/02)

The invention provides novel chiral comp...

Probing the parallel resolution of Mosher's acid using a combination of quasi-enantiomeric oxazolidin-2-ones

Chavda, Sameer,Coulbeck, Elliot,Dingjan, Marco,Eames, Jason,Motevalli, Majid

, p. 1274 - 1284 (2008/12/20)

Mosher's acid (2-methoxy-2-phenyl-2-trif...

20445-31-2 Process route

C<sub>26</sub>H<sub>31</sub>F<sub>3</sub>O<sub>3</sub>

C26 H31 F3 O3

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid
20445-31-2

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

(-)-8-phenylmenthol
65253-04-5

(-)-8-phenylmenthol

Conditions
Conditions Yield
With potassium hydroxide; In methanol; at 70 ℃; Schlenk technique; Inert atmosphere;
99%
95%
C<sub>25</sub>H<sub>29</sub>F<sub>3</sub>O<sub>3</sub>

C25 H29 F3 O3

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid
20445-31-2

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

(-)-8-phenylmenthol
65253-04-5

(-)-8-phenylmenthol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Molecular sieve; Schlenk technique
1.2: 0 - 20 °C / Inert atmosphere; Molecular sieve; Schlenk technique
2.1: potassium hydroxide / methanol / 70 °C / Schlenk technique; Inert atmosphere
With sodium hydride; potassium hydroxide; In tetrahydrofuran; methanol;

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20445-31-2 Downstream products

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  • 129866-73-5
    129866-73-5

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    129866-73-5

    (2R,3S)-3-Phenyl-1-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-aziridine-2-carboxylic acid methyl ester

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